Fractional CO2 Laser Explained: How It Works

June 26, 2026
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Evolve Wellness & Aesthetics
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Woman with a subtle fractional treatment pattern illustrating modern CO2 laser skin resurfacing.

Laser resurfacing has changed significantly over the years.

Earlier treatments often resurfaced an entire area of skin at once. Although those procedures could produce meaningful improvement, they could also require a substantial healing period.

Fractional technology introduced a different approach.

Instead of treating every part of the skin’s surface, a fractional CO2 laser creates a controlled pattern of microscopic treatment zones. Small areas are treated while surrounding tissue remains intact, helping support the skin’s natural repair process.

This ability to treat only a fraction of the skin at one time is what gives fractional laser resurfacing its name.

Today, fractional CO2 technology allows qualified providers to adjust treatment depth, density and intensity based on the patient’s skin, concerns and desired recovery experience.

But what does “fractional” actually mean—and how is it different from other laser treatments?

What Is a Fractional CO2 Laser?

A fractional CO2 laser is an ablative resurfacing device that uses carbon dioxide laser energy to create microscopic columns of controlled injury in the skin.

These columns are often described as microscopic treatment zones.

Between the treated columns are areas of untouched skin. This surrounding tissue helps the skin begin repairing itself after treatment. Fractional CO2 resurfacing was developed to retain many of the rejuvenating capabilities associated with CO2 laser technology while reducing recovery and complications compared with older, fully ablative techniques.

The treatment can be customized by adjusting factors such as:

  • Treatment depth
  • Energy level
  • Spacing between treatment zones
  • Percentage of skin treated
  • Number of passes
  • Pulse duration

These settings influence both the treatment’s intensity and the recovery experience.

A lighter treatment may focus primarily on superficial texture and overall skin quality. A more intensive fractional treatment may reach deeper tissue when greater correction is appropriate.

That flexibility is one of the most important characteristics of modern fractional CO2 technology.

What Does “Ablative” Mean?

Laser resurfacing treatments are generally described as either ablative or nonablative.

An ablative laser removes or vaporizes microscopic portions of tissue. A nonablative laser delivers energy below the skin’s surface without removing the outer layer in the same way.

Fractional technology can be used with both ablative and nonablative systems. The word “fractional” describes the treatment pattern—not whether the laser is ablative or nonablative. The Mayo Clinic notes that both types of laser resurfacing can be delivered fractionally by creating microscopic columns of treated tissue.

A fractional CO2 laser is therefore:

  • Fractional, because it treats the skin in a patterned series of microscopic zones
  • Ablative, because it removes controlled columns of tissue
  • CO2, because it uses carbon dioxide laser energy

Understanding these terms makes it easier to compare treatment options without assuming every “fractional laser” works the same way.

How Fractional CO2 Resurfacing WorksIllustration showing microscopic fractional CO2 laser treatment zones surrounded by intact skin tissue.

When fractional CO2 energy reaches the skin, it creates thousands of tiny treatment channels.

The body recognizes these channels as controlled injuries and begins a healing response. Older or damaged tissue is replaced as the skin repairs itself, while collagen remodeling takes place below the surface.

Collagen is one of the structural proteins that helps support the skin. As part of the repair process, the treated area may gradually appear smoother, firmer and more even.

Research has supported the use of fractional ablative resurfacing for concerns associated with photoaging, including changes in skin texture and pigmentation.

The improvement does not happen entirely on the day of treatment.

Some visible changes may emerge as the surface heals, while collagen remodeling can continue over the weeks and months that follow.

Why Leave Surrounding Skin Untreated?

The untreated tissue between microscopic treatment zones is one of the defining features of fractional resurfacing.

Think of the treatment pattern as a grid rather than a solid sheet.

In a fully ablative treatment, the entire surface within the treatment area may be affected. In a fractional procedure, small sections remain untouched between the laser-created columns.

Those untreated areas provide a source of healthy cells that can help support re-epithelialization and healing.

This does not mean a fractional treatment has no downtime. Redness, swelling, sensitivity, peeling and temporary changes in skin appearance can still occur.

However, fractionation was developed in part to reduce healing demands and complication rates compared with older nonfractionated CO2 resurfacing.

What Can Fractional CO2 Laser Resurfacing Address?

Depending on the treatment settings and the individual patient, fractional CO2 resurfacing may be considered for concerns such as:

  • Fine lines and wrinkles
  • Rough or uneven texture
  • Visible sun damage
  • Acne scars
  • Enlarged-looking pores
  • Uneven skin tone
  • Overall skin quality

CO2 lasers are also used medically for a variety of other skin conditions, but cosmetic resurfacing plans should be selected according to the patient’s specific concern, skin characteristics and medical history.

Not every concern requires the same level of treatment.

For example, mild textural changes may call for a different approach than deeper acne scarring or more established wrinkles. A provider may also recommend a series of lighter treatments rather than one more intensive session.

Treatment Depth Is Only Part of the EquationIllustration showing customizable fractional CO2 laser treatment depths and corresponding recovery levels.

Patients often assume that a deeper treatment is automatically a better treatment.

That is not necessarily true.

The appropriate treatment depends on what the patient wants to improve, how much recovery is acceptable and how the skin is likely to respond.

A provider must consider several variables, including:

  • Skin type and tone
  • Current skin condition
  • History of pigmentation changes
  • Previous treatments
  • Tendency to scar
  • History of cold sores
  • Medications
  • Recent sun exposure
  • Treatment goals
  • Available recovery time

Deeper resurfacing may provide more correction for certain concerns, but it generally involves a more involved recovery and greater responsibility for post-treatment care.

A lighter approach may be more appropriate for someone seeking gradual improvement with less interruption to daily life.

The goal should not be to use the most aggressive setting possible. It should be to choose the setting that appropriately balances improvement, safety and recovery.

Where Does CoolPeel Fit In?

CoolPeel is a specific fractional CO2 treatment approach designed to target more superficial tissue while limiting unnecessary heat in surrounding skin.

It is performed using compatible DEKA CO2 technology rather than being a separate type of laser.

DEKA describes its Tetra PRO platform as a system that can deliver micro-ablative procedures using adjustable pulse options for different skin conditions and treatment areas.

CoolPeel may be appropriate for patients who want to improve skin quality with a more manageable recovery experience. Other patients may benefit from a more intensive fractional CO2 treatment.

That is why CoolPeel and deeper fractional resurfacing should not be viewed as competing technologies. They are different treatment approaches that can exist along the same resurfacing spectrum.

For a detailed comparison, read:

CoolPeel vs Traditional CO2 Laser Resurfacing: What’s the Difference?

What Is Recovery Like?

Recovery varies substantially.

A superficial fractional treatment may produce temporary redness, warmth, dryness or a sandpaper-like texture. More intensive resurfacing may involve swelling, crusting, peeling and a longer period before the skin looks and feels fully healed.

The American Society for Dermatologic Surgery lists a healing range of approximately three to ten days for CO2 laser resurfacing, while the American Society of Plastic Surgeons notes that recovery from CO2 resurfacing can extend to approximately two weeks. The actual timeline depends heavily on treatment intensity and individual healing.

Patients should follow their provider’s aftercare instructions closely.

Post-treatment guidance may include:

  • Using recommended cleansers and ointments
  • Avoiding picking or exfoliating
  • Limiting sun exposure
  • Wearing appropriate sun protection
  • Pausing certain active skincare products
  • Avoiding excessive heat or strenuous activity temporarily
  • Contacting the practice if unexpected symptoms develop

Because fractional CO2 resurfacing intentionally disrupts the skin barrier, aftercare is part of the treatment—not an optional extra.

Is Fractional CO2 Laser Resurfacing Right for Everyone?

No laser treatment is right for every person.

Certain skin tones may have a greater risk of post-inflammatory pigmentation changes, and some medical conditions, medications or healing concerns may affect candidacy.

Potential risks can include prolonged redness, infection, acne-like eruptions, changes in pigmentation and, less commonly, scarring. Fractional technology may lower some risks compared with fully ablative resurfacing, but it does not eliminate them.

A consultation should include an evaluation of:

  • The condition being treated
  • Skin type and pigmentation
  • Medical and medication history
  • Previous procedures
  • Expected benefits
  • Recovery requirements
  • Possible risks
  • Alternative treatments

The provider’s experience with fractional CO2 technology and individualized treatment planning matters just as much as the device itself.

Fractional Does Not Mean One-Size-Fits-All

The most important thing to understand about fractional CO2 resurfacing is that it is not one standardized treatment.

Two patients may receive fractional CO2 laser treatment using completely different settings.

One may receive a light resurfacing session targeting texture and radiance. Another may undergo a deeper treatment intended to address more significant wrinkles or scarring.

Both may accurately be called fractional CO2 resurfacing.

That is why comparing treatments only by name can be misleading. The treatment pattern, depth, density, pulse structure and provider’s technique all help determine the experience and outcome.

The Bottom Line

Fractional CO2 laser resurfacing works by creating microscopic treatment zones while preserving surrounding areas of skin.  This patterned approach allows the skin to begin repairing itself from both the treated columns and the healthy tissue between them.

Modern systems can be adjusted for different depths and treatment goals, giving patients more options than earlier generations of CO2 resurfacing. The right treatment is not necessarily the deepest or strongest option. It is the treatment selected thoughtfully for your skin, your concerns and the recovery experience you are prepared for.

At Evolve Wellness & Aesthetics, fractional CO2 treatments are customized following an evaluation of your skin and treatment goals.

To learn more about available options, visit our CO2 Laser Resurfacing in Tucson page or schedule a personalized consultation.